Rhus dating

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Rhus Tox decreased oxidative stress and cytokine release with restoration of anti-oxidant systems.Chronic treatment with Rhus Tox ultra dilutions for 14 days ameliorated neuropathic pain revealed as inhibition of cold, warm and mechanical allodynia along with improved motor nerve conduction velocity (MNCV) in constricted nerve.In continuation, we evaluated antinociceptive efficacy of Rhus Tox in the neuropathic pain and delineated its underlying mechanism.Initially, in-vitro assay using LPS-mediated ROS-induced U-87 glioblastoma cells was performed to study the effect of Rhus Tox on reactive oxygen species (ROS), anti-oxidant status and cytokine profile.Gabapentin served as a positive control in this study.The treatment of U-87 cells with LPS resulted into a marked increase in the cell viability.Protective effect of Rhus Tox against CCI-induced sciatic nerve injury in histopathology study was exhibited through maintenance of normal nerve architecture and inhibition of inflammatory changes.Overall, neuroprotective effect of Rhus Tox in CCI-induced neuropathic pain suggests the involvement of anti-oxidative and anti-inflammatory mechanisms..

Despite the emergence of novel drug discovery technologies and advancements in the field of neuroscience, the issue of neuropathic pain management with safe and effective remedies is still unresolved.In this report, we demonstrated antinociceptive effects of RT in neuropathic pain using in-vitro and in-vivo assays.Initially, in-vitro study using U-87 primary glioblastoma cell line was executed to delineate the effect of RT on LPS-induced ROS production, anti-oxidant status and cytokine levels.It is manifested as sensory abnormalities like dysesthesia (unpleasant sensation), hyperalgesia (increased sensitivity to noxious stimuli), allodynia (increased sensitivity to non-noxious stimuli) and spontaneous development of pain.Neuropathic pain has a complex pathology with distinct mechanisms.

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